Fig. 2. The effects of propofol (intraperitoneally) were determined by the anesthetic score obtained for each cumulative dose in rats that sustained intraventricular injections (icv) of 192 immunoglobulin G–saporin (sapo; n = 14) or phosphate-buffered saline solution (sham; n = 6). Results are expressed as mean ± SEM. (  A ) Subanesthetic state set by repeated administration of 25 mg/kg propofol. (  B ) Anesthetic state set by repeated administration of 50 mg/kg propofol. *  P < 0.05 compared with SHAM-operated animals.