Fig. 6. Neonatal exposure of mice to sevoflurane (Sevo) induced impaired memory performance in both contextual and cued tests. (  A and  B ) Contextual and cued tests at 8 weeks of age. (  A ) Freezing response was measured in the context before shock (basal freezing) and in the conditioning chamber (contextual fear response) 24 h after conditioning (control, n = 8; sevoflurane, n = 8). (  B ) Freezing response (for the same set of mice as in  A ) was measured in an alternative context without auditory cue (basal freezing after conditioning) or with cue 2 days after conditioning. (  C and  D ) Contextual and cued tests for another set of mice at a different age (14–17 weeks of age) as in  A and  B (control, n = 9; sevoflurane, n = 9). For all figures,  asterisks represent statistical difference (*  P < 0.05, **  P < 0.01).