Fig. 3.
Field stimulation evokes Ca2+ transients through generation of action potentials. (A) Field stimulation (2-ms pulses at 10 Hz) produces R340/380 transients in dorsal root ganglion neurons in an all-or-none fashion, indicated by a threshold for eliciting transients with incrementally increasing stimulation voltage (5, 10, 15, 20, 30 V; n = 10). (B) Lidocaine (1 mm) reversibly abolishes field stimulation-evoked R340/380 transients but does not block K+-induced R340/380 transients (note differenttime scales; n = 15).