Von Frey test and spontaneous activity (SA) data from the previous three figures combined. (A) The von Frey behavior data from the locally inflamed dorsal root ganglia (LID) groups in each experiment were similar (two-way repeated-measures ANOVA) and have been combined (red, no added drug, N = 19). For drugs applied locally to the dorsal root ganglia at the time of dorsal root ganglia inflammation, the glucocorticoid receptor (GR)–selective agonist (fluticasone, blue) gave the largest reduction in hypersensitivity (paw withdrawal threshold [PWT]). 6-α Methylprednisolone (gray), which activates both mineralocorticoid receptor (MR) and GR in vitro, gives a more modest effect and its effect is larger when MR effects are simultaneously blocked with an MR antagonist eplerenone (EPL) (green). Two-way repeated-measures ANOVA with Bonferroni post-test comparing each group with every other group indicated that all points with nonoverlapping SEM bars were significantly different from one another. (B) The data on SA from the three previous figures are combined. ***P < 0.001, significant difference between normal and LID groups; #P < 0.05, significantly different from LID group (chi-square test).