Figure 1. Protocol design for each of treatment days. A = algesimetry, R = respiratory testing, VAS = visual analog scale; DS = digit symbol substitution test; OS = observer score. Vertical arrows signify times of blood sampling.

Figure 1. Protocol design for each of treatment days. A = algesimetry, R = respiratory testing, VAS = visual analog scale; DS = digit symbol substitution test; OS = observer score. Vertical arrows signify times of blood sampling.

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