Figure 3. The two graphs show the percent of tests wherein subjects reported hyposensitivity to pinprick (top) and cold (bottom), expressed as percent of all tests performed at each dermatome at all times after administration of the epidural solution. All subjects had a normal perception of pinprick and cold at all dermatomes before injection. Epinephrine caused hyposensitivity to pinprick in 40% of subjects (P <0.0001, placebo as reference) at L1-L4-S1 (P < 0.0001, forehead-T1-T6-T9 as reference). Clonidine caused hyposensitivity to pinprick in 40% and cold in 33% of subjects (P < 0.0001 in both analyses, placebo as reference) at L1-L4-S1 (P < 0.0001 in both analyses, forehead-T1-T6-T9 as reference). *P < 0.0001.