Fig. 2.
Time to near-complete recovery across doses for hotplate, Von Frey testing, and extensor postural thrust in the injected limb (A–C) and the contralateral limb (D–F). Horizontal lines represent median value, boxes represent interquartile range, and whiskers represent minimum–maximum values. For the injected limb, Kruskal–Wallis tests showed significant differences between doses on time to near-complete recovery for both the Neosaxitoxin-saline (NeoSTX-Saline) (hotplate P < 0.001, Von Frey P = 0.019, extensor postural thrust P < 0.001) and Neosaxitoxin-Bupivacaine (NeoSTX-Bup) (hotplate P < 0.001, Von Frey P < 0.001, extensor postural thrust P < 0.001). For the contralateral limb, Kruskal–Wallis tests showed a significant difference between doses for NeoSTX-Saline (hotplate test P < 0.001) and NeoSTX-Bup (hotplate P < 0.001 and extensor postural thrust P < 0.001). Comparisons have been presented for NeoSTX-Saline versus NeoSTX-Bup using Mann–Whitney tests at each Neosaxitoxin (NeoSTX) dose.