Mean arterial blood pressure (A) and heart rate (B) evolution during the experimental period. Values (given as mean ± SD) were measured at baseline, just before fluid resuscitation, after 15 min of fluid resuscitation, and after 4 h of saline or ivabradine infusion. *P < 0.05 as compared with the nonseptic, fluid resuscitated and treated with saline (n = 7; SHAM) group at the same time point. †P < 0.05 as compared with the septic, fluid resuscitated and treated with saline (n = 7; CLP-SALINE) group at the same time point. bpm = beats/min; CLP = cecal ligation and puncture procedure; CLP-IVABRADINE group = septic, fluid resuscitated with saline and treated with ivabradine (n = 7).