Fig. 5.
TNF-α and IL-6 production in response to different stimulation in the presence and absence of CIS and PAN. (A–D) Levels of TNF-α and IL-6 released from CD14+ cells after LPS stimulation for 4 h. (E and F) Levels of IL-6 released from human endothelial cells (ECV304) after LPS stimulation for 4 h in the presence or absence of CIS or PAN. (G and H) Levels of IL-6 and TNF-α in lung lavage fluids from the perfused mouse lung model after LPS challenge in the presence or absence of CIS. CIS = cisatracurium; ECV304 = human endothelial cells; IL-6 = interleukin-6; LPS = lipopolysaccharide; PAN = pancuronium; TNF-α = tumor necrosis factor-α. *P < 0.05 CIS 0.32 and 0.64 μM versus control. **P < 0.05 PAN 1.4, 3.5 μM versus control. °P < 0.05 LPS + CIS versus LPS.