Fig. 2.
Nonlinear regression of the dose–response of CW002 for neuromuscular blockade (twitch inhibition) in the isoflurane-anesthetized Rhesus monkey. Scales: x-axis, logarithmic; y-axis, arithmetic. First and second doses of each experiment only were used for the calculations. Twitch was elicited at 0.15 Hz; 33 data points are shown. ED50 and ED95 (red points) indicate effective doses (milligram per kilogram) resulting in 50 and 95% twitch inhibition, respectively. Vertical bars indicate SD; n = number of responses (data points) observed at 100% twitch inhibition at each dose of CW002.