Fig. 4.
Murine studies: activated protein C is central to fibrinolysis in acute traumatic coagulopathy. A, Attenuation of fibrinolytic activity in thrombomodulin knockin (TMKI) mice subjected to trauma hemorrhage (TH); *P < 0.05 (wild-type [WT]: time 0 [T0] vs. WT: time 60 min [T60]; WT: T60 vs. TMKI: T60). B, In WT mice after TH, fibrinogen fell significantly, but TMKI animals were protected from this fibrinogen depletion; *P < 0.05 (WT: T0 vs. WT: T60) and (WT: T60 vs. TMKI: T60). C, Improved median survival times after TH in TMKI mice versus WT (*P < 0.05).