Figure 1. Time course of the inhibitory effect of propofol on L-type calcium current (ICa(L)). (A) Original current tracings ICa(L) were recorded in the absence (a), the presence of 56 micro Meter propofol (b), and washout of propofol (c) at the time corresponding to that in (B). Holding potential was -50 mV and a step depolarization to +10 mV. Pulse duration was 300 ms and stimulation frequency was 0.2 Hz. Time zero indicates the moment immediately after breaking the patch. Note that the time course of the decrease in ICa(L) by propofol can be separated easily from that of spontaneous rundown.
