Figure 6. Frequency-dependent block of ICa(L) by propofol. (A) Original current tracings of ICa(L) in the absence (c1 to c6) and presence of 56 micro Meter propofol (d1 to d6). ICa(L) was elicited during a train-of-six depolarizing pulse from a holding potential of -50 mV to a test potential of +10 mV. Pulse duration was 300 ms and stimulation frequencies were 0.5, 1, and 2 Hz, respectively. (B) The time course of the peak amplitude of ICa(L) obtained from A. (C) The normalized time course of development of use-dependent block of ICa(L) by 56 micro Meter propofol. (open symbols = control; filled symbols = 56 micro Meter propofol).

Figure 6. Frequency-dependent block of ICa(L) by propofol. (A) Original current tracings of ICa(L) in the absence (c1 to c6) and presence of 56 micro Meter propofol (d1 to d6). ICa(L) was elicited during a train-of-six depolarizing pulse from a holding potential of -50 mV to a test potential of +10 mV. Pulse duration was 300 ms and stimulation frequencies were 0.5, 1, and 2 Hz, respectively. (B) The time course of the peak amplitude of ICa(L) obtained from A. (C) The normalized time course of development of use-dependent block of ICa(L) by 56 micro Meter propofol. (open symbols = control; filled symbols = 56 micro Meter propofol).

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