Figure 10. The proposed signal transduction mediating isoproterenol- or acetylcholine-evoked NO-cGMP relaxation pathway. AC = adenylyl cyclase; ACh = acetylcholine; mAChR = muscarinic acetylcholine receptor; BetaR = beta-adrenoceptor; cNOS = constitutive nitric oxide synthase; IP sub 3 = inositol triphosphate; Kca = Calcium²+ activated potassium channel; PLC = phospholipase C; sGC = soluble guanylyl cyclase. Left and right side (separated by two parallel dotted lines) of the diagram show the acetylcholine- and isoproterenol-evoked NO-cGMP pathway, respectively.