Electroencephalographic and electromyographic signals recorded from a dog (in the 186 mg/kg group) that had a seizure after receiving a 6 mg/kg ABP-700 bolus immediately followed by a 2-h ABP-700 infusion at 1.5 mg · kg^-1 · min^-1 (A) upon initiation of the seizure 107.5 min after beginning ABP-700 administration (i.e., after receiving 167 mg/kg of ABP-700), (B) during the seizure, and (C) upon spontaneous termination of the seizure 1.4 min after it began. (D) Timing of all seizures in Beagle dogs. Five dogs had electroencephalographically-confirmed seizures. Two dogs received 126 mg/kg ABP-700 (black symbols), two dogs received 186 mg/kg ABP-700 (blue symbols), and one dog received 282 mg/kg ABP-700 (red symbols). The only seizure that occurred during ABP-700 administration is highlighted by a yellow star. In one dog in the 126 mg/kg group, two seizures occurred within 6 min of one another (T = 13.15 and 13.24 h). Consequently, their symbols largely overlap. The number of seizures that each dog had during the study period is also numerically indicated. The gray bar highlights the 2-h time period when ABP-700 was administered.