Toxicokinetics of (A) ABP-700 and (B) its principal metabolite CPM-acid in Beagle dogs. T = 0 is the time of ABP-700 bolus administration (6 mg/kg), which was immediately followed by a 2-h ABP-700 infusion at 1 mg · kg^-1 · min^-1 (126 mg/kg total dose), 1.5 mg · kg^-1 · min^-1 (186 mg/kg total dose), or 2.3 mg · kg^-1 · min^-1 (282 mg/kg total dose). The left and right vertical axes report concentrations in units of ng/ml and μM, respectively. In each, individual datasets obtained using a single dog are represented by connected symbols. Data from dogs that had electroencephalographically confirmed seizures are shown as red and blue data points. The time when each of the five dogs had their first seizure is also indicated in each panel by an arrow, which is color-coded to the dog. In each panel, the gray bar highlights the 2-h time period when ABP-700 was administered. Values below the lower limits of quantitation (1.00 ng/ml and 20.0 ng/ml for ABP-700 and CPM-acid, respectively) were not plotted.