Thrombin generation. Lag time (A), peak height (B), and endogenous thrombin potential (ETP; C) are shown. Horizontal dotted lines indicate baseline values before anticoagulation. Data are shown as mean ± SD; in each group, n = 9 animals initially. In control and tranexamic acid (TXA) plus human fibrinogen concentrate (FCH) animals (TXA–FCH), no thrombin generation could be detected later than 60 min posttrauma. *P < 0.05 versus control group; †P < 0.05 versus TXA–FCH group; ‡P < 0.05 versus prothrombin complex concentrate (PCC) 25 U/kg group (PCC25); §P < 0.05 versus PCC 50 U/kg group (PCC50). Between-group differences are presented hierarchically as follows: idarucizumab (IDA) (§‡†*) → PCC50 (‡†*) → PCC25 (†*) → TXA–FCH (*) → control.