Fig. 1.
Schematic of the pharmacokinetic/pharmacodynamic model. CL = clearance from the central compartment; IV = intravenous; Kout = first-order rate constant for drug leaving the effect compartment; Q1–3 = distributional clearance from the central compartment to peripheral compartments; Tau = first-order rate constant for drug into transit and effect compartments; V1–4 = volume for central and peripheral compartments.