Fig. 7.
Likelihood profiles are displayed for each parameter estimated in the population pharmacokinetic analysis. The x axis shows the values estimated (red circle) or fixed (blue circles) in the analysis. The y axis shows the change in the minimum value of the objective function (MVOF) compared to the NONMEM run in which the value for that parameter is estimated. Dashed horizontal lines mark increases of 3.84 and 6.64 in the minimum value of the objective function, associated with P values of 0.05 and 0.01, respectively. CL = clearance; CLdist = distribution clearance; F = relative bioavailability; ka = absorption rate; V1 = central volume.