Vascular permeability after lipopolysaccharide (LPS). LPS increased Evans blue leakage into ascites and lung. Notably, guanylyl cyclase A deletion in endothelial cells (ecGCA-KO) increased this response to LPS (n = 5 per group). *P < 0.05 versus saline-injected non-LPS mice, #P < 0.05 versus floxed mice.