Figure 3. Percentage segment shortening (%SS)in the ischemic and reperfused left anterior descending coronary artery (LAD) region. Percentage segment shortening was significantly (P < 0.05) decreased from baseline during each 5-min LAD occlusion in all groups. Dogs pretreated with drug vehicle maintained %SS at baseline values only during the first 5-min reperfusion period; thereafter, %SS decreased from baseline during each reperfusion period. Significant decreases in %SS during each 5-min reperfusion and throughout 180 min of the final reperfusion were observed in glyburide-pretreated dogs in the presence and absence of isoflurane. Regional contractile function recovered to baseline values during the first and second 5-min reperfusions and 60, 120, and 180 min after the final reperfusion in dogs receiving isoflurane alone. (dagger)Significantly (P < 0.05) different from drug vehicle-pretreated dogs;(section)significantly (P < 0.05) different from glyburide-pretreated dogs; and (double dagger)significantly (P <0.05) different from dogs receiving glyburide and isoflurane.