Fig. 3.
Astrocyte-specific knockout (KO) of Ndufs4 causes hysteresis between induction and emergence in tail clamp. (A) The change in the anesthetic concentration (Δ Anesthetic Concentration) between induction and emergence required to respond to tail clamp before and after exposure to isoflurane (ISO) or halothane (HAL), at 3 weeks postinjection of 4-hydroxy tamoxifen. N = 6 for control; N = 7 for the astrocyte-specific Ndufs4(KO). (B) The change in the anesthetic concentration required to respond to tail clamp before and after exposure to isoflurane or halothane at 7 weeks postinjection of 4-hydroxy tamoxifen. N = 6 for control and the astrocyte-specific Ndufs4(KO). Tests for significance were done on the difference between the EC50s for induction and emergence: ***P < 0.001. The error bars represent SD.

Astrocyte-specific knockout (KO) of Ndufs4 causes hysteresis between induction and emergence in tail clamp. (A) The change in the anesthetic concentration (Δ Anesthetic Concentration) between induction and emergence required to respond to tail clamp before and after exposure to isoflurane (ISO) or halothane (HAL), at 3 weeks postinjection of 4-hydroxy tamoxifen. N = 6 for control; N = 7 for the astrocyte-specific Ndufs4(KO). (B) The change in the anesthetic concentration required to respond to tail clamp before and after exposure to isoflurane or halothane at 7 weeks postinjection of 4-hydroxy tamoxifen. N = 6 for control and the astrocyte-specific Ndufs4(KO). Tests for significance were done on the difference between the EC50s for induction and emergence: ***P < 0.001. The error bars represent SD.

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