American Society of Anesthesiologists

Fig. 3.

Potentiation of α1β3γ2L γ-aminobutyric acid type A receptor currents by etomidate and etomidate analogs containing phenyl ring substituent groups. (A) Electrophysiologic traces showing the potentiating effect of these drugs (all at 100 µM) on currents evoked by a γ-aminobutyric acid (GABA) concentration that elicits 5% of the current evoked by 1 mM GABA (EC5 GABA). The amplitude of each trace is normalized to that evoked by EC5 GABA alone, which is indicated by the dashed red line. (B) Etomidate and etomidate analog concentration-response curves for potentiation of EC5 GABA-evoked currents. Each symbol is the mean ± SD derived from four different oocytes. The curves are fits of the datasets to equation 1 with the fitted results given in table 1.

Potentiation of α₁β₃γ_2L γ-aminobutyric acid type A receptor currents by etomidate and etomidate analogs containing phenyl ring substituent groups. (A) Electrophysiologic traces showing the potentiating effect of these drugs (all at 100 µM) on currents evoked by a γ-aminobutyric acid (GABA) concentration that elicits 5% of the current evoked by 1 mM GABA (EC₅ GABA). The amplitude of each trace is normalized to that evoked by EC₅ GABA alone, which is indicated by the dashed red line. (B) Etomidate and etomidate analog concentration-response curves for potentiation of EC₅ GABA-evoked currents. Each symbol is the mean ± SD derived from four different oocytes. The curves are fits of the datasets to equation 1 with the fitted results given in table 1.

This Feature Is Available To Subscribers Only