Fig. 4.
The relationship between the logarithm of a drug’s EC50 (A) or the maximal peak current that a drug elicits at high concentrations (B) and the size of its phenyl ring substituent group. Substituent group volume is expressed as the increase over that of etomidate. Each data point and its 95% CI were derived by fitting the drug concentration-response curves for potentiation of 5% of the current evoked by 1 mM γ-aminobutyric acid (GABA) shown in fig. 3 to equation 1. The line in each is a linear least squares fit of the dataset.
