American Society of Anesthesiologists

Fig. 7.

Potentiation of wild-type α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor currents or mutant α1β3(N265M)γ2L GABAA receptor currents by 100 µM naphthalene-etomidate. (A) Electrophysiologic traces showing the effect of naphthalene-etomidate on currents evoked by a γ-aminobutyric acid (GABA) concentration that elicits 5% of the current evoked by 1 mM GABA (EC5 GABA) and mediated by either wild-type (left) or mutant α1β3(N265M)γ2L (right) GABAA receptors. (B) Summary data (n = 6 oocytes/experimental condition) showing the impact of 100 µM naphthalene-etomidate on currents evoked by EC5 GABA and mediated by either wild-type (left) or mutant α1β3(N265M)γ2L (right) GABAA receptors. In this panel, each symbol represents data obtained from a single oocyte, and the lines indicate the mean ± SD of each dataset. N.S. = not significant. **P = 0.002.

Potentiation of wild-type α₁β₃γ_2L γ-aminobutyric acid type A (GABA_A) receptor currents or mutant α₁β₃(N265M)γ_2L GABA_A receptor currents by 100 µM naphthalene-etomidate. (A) Electrophysiologic traces showing the effect of naphthalene-etomidate on currents evoked by a γ-aminobutyric acid (GABA) concentration that elicits 5% of the current evoked by 1 mM GABA (EC₅ GABA) and mediated by either wild-type (left) or mutant α₁β₃(N265M)γ_2L (right) GABA_A receptors. (B) Summary data (n = 6 oocytes/experimental condition) showing the impact of 100 µM naphthalene-etomidate on currents evoked by EC₅ GABA and mediated by either wild-type (left) or mutant α₁β₃(N265M)γ_2L (right) GABA_A receptors. In this panel, each symbol represents data obtained from a single oocyte, and the lines indicate the mean ± SD of each dataset. N.S. = not significant. **P = 0.002.

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