Fig. A1.1.
Synthesis of CW 1759-50: The scheme for CW 1759-50 shows esterification of the amino alcohol 1972-25 with maleic anhydride in triethylamine (Et3N) and acetonitrile to yield the monoester 1972-38. Treatment of the monoester with the (second) amino alcohol 1972-11 in oxalyl chloride and 1,2-dichloroethane yields the diester CW 1759-50. Synthesis of gantacurium chloride (GW280430A): The synthesis of gantacurium has been described.3 The scheme shown is analogous to the scheme for CW 1759-50, showing the final steps from advanced intermediates to the desired product, gantacurium.
