Figure 4. The probability of response as a function of drug concentration, normalized to <C⁵⁰>. Simulated data were generated assuming that the mean value of gamma = 10 (gamma is log-normal distributed with a standard deviation of 0.5) and that omega = 1. Shown are the concentration-response curves for the typical patient with gamma = 10 ([center dot]), the curve estimated using population probit analysis (Equation 4)([center dot]), and the curve estimated with naive probit analysis (Equation 2)([center dot]).