Figure 6. Hypnotic response to dexmedetomidine 100 micro gram *symbol* kg sup -1 intraperitoneally in rats after various time intervals after treatment with N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ). Separate groups of rats were administered EEDQ, 0, 0.1, 0.2, and 0.3 mg *symbol* kg sup -1 subcutaneously 1, 3, and 8 days later, their hypnotic response to dexmedetomidine 100 micro gram *symbol* kg sup -1 intraperitoneally was tested. Data are expressed as duration of loss of righting reflex (LORR). Data were analyzed by analysis of variance and post hoc Scheffe test where appropriate. *P < 0.05. n = 7 or 8 per group.