Figure 10. Open- and closed-time distributions of N-methyl-D-aspartate receptors recorded in the outside-out configuration. (A) The open-duration histogram was fitted with the sum of two exponential functions that had fast and slow time constants (ms) and relative areas of tau¹= 0.74 ms, a¹0.26, tau²= 3.6 ms, a²= 0.75. (B) In the presence of 1 micro Meter ketamine, tau¹= 0.81 ms, a¹0.2, tau²= 4.1 ms and a²= 0.81. (C) The closed-duration histograms were best fit with three exponential functions. Under control conditions, tau¹= 0.60 ms, a¹= 0.6, tau²= 8.11 ms, a²= 0.16, tau³= 39.47 ms, a³= 0.25, whereas tau¹= 0.8 ms, a¹= 0.6, tau sub 2 = 7.6 ms, a²= 0.09, tau³= 65 ms and a³= 0.34 in the presence of ketamine (D).