Figure 1. Current from alpha4beta2-expressing oocytes and inhibition by isoflurane and propofol. Inhibition of macroscopic currents by propofol and isoflurane. (A) An oocyte expressing alpha4beta2 receptors, 2.4 micro Ampere of current in response to 1 micro Meter acetylcholine. The same application of acetylcholine coapplied with 320 micro Meter isoflurane reduces the macroscopic current to 1.1 micro Ampere (46% of control). (B) An oocyte expressing alpha4beta2 receptors, as in A, produces 1.4 micro Ampere of current in response to 1 micro Meter acetylcholine. The same application in the presence of 400 nM propofol reduces the current to 0.3 micro Ampere (21% of control).