Figure 3. Lemakalim dose-response relationship measured in seven dogs after U46619 preconstriction in the conscious state and during halothane anesthesia. Vasodilator response to lemakalim is expressed as the percentage decrease in U46619 preconstriction (defined in Methods section). Lemakalim-induced pulmonary vasodilation (*P < 0.05) was attenuated (*P < 0.05) during halothane anesthesia compared with the conscious state.