Figure 8. Lemakalim dose-response relationship measured in three dogs after U46619 preconstriction in the conscious state and during halothane anesthesia. Vasodilator response to lemakalim is expressed as the percentage decrease in U46619 preconstriction (defined in Methods section). In the conscious state, combined neurohumoral block did not alter the magnitude of the pulmonary vasodilator response to lemakalim. The attenuated ((dagger)P < 0.05) pulmonary vasodilator response to lemakalim during halothane anesthesia was still apparent after combined neurohumoral block.