Figure 5. Values for clearance (Cl) of rHb1.1 determined from NONMEM's post hoc step are plotted against the dose of rHb1.1. Values for Cl were obtained from a one-compartment model in which weight-normalized pharmacokinetic parameters were equal for all volunteers and Cl did not vary with plasma concentration or dose of rHb1.1. The thin line, determined using a smoother (Supersmoother), suggests that the assumption of the same Cl for all volunteers is incorrect.