Figure 4. Area under the time-effect curve (AUC; mean +/- SEM) for thermally evoked hind paw withdrawal observed after the intrathecal injection of substance P (IT sP; 30 nmol) in groups of rats treated with intraperitoneal gabapentin (100 mg/kg) at 180, 60, 15, or 2 min before or 10 min after the injection of IT sP. The dashed lines indicate +/- 1 SEM of the effect produced by IT sP alone. One-way analysis of variance revealed a significant treatment effect between groups (P < 0.001). Post hoc comparisons indicated that 180 min before treatment was not different from IT sP + saline, whereas significant suppression of hyperalgesia was observed by treatment 60 to 2 min before and 10 min after IT sP (P < 0.05).