Figure 5. Concentration dependency of isoflurane modulation for the four receptor isoforms. (A) Representative example (alpha beta gamma delta) for the nominal concentrations (left to right) of 58, 147, 294, 440, 587, 1,175, and 2,879 micro Meter of isoflurane (ISO) on response to 5 micro Meter of GABA, depicting the bell-shaped nature of the effect seen for all isoforms (scale bar represents 1,000 nA). (B) Compounded data (mean +/- SEM) for each combination (fitted by nonlinear regression up to the maximum only for each curve).