Figure 6. Summary of the depressant effects of isoproterenol in combination with anesthetics. Data from 6 to 12 cells per experimental set are shown in the absence and presence of GDP beta S or PKI-(6–22)-amide. The reduction of peak I^Naby isoproterenol was analyzed from the steady state obtained during anesthetic exposure, as shown by the dotted lines in Figure 1and Figure 4. Error bars denote SEM;* significantly different versus steady-state of anesthetic effect;+ significantly different versus isoproterenol in combination with isoflurane plus GDP beta S;# significantly different versus isoproterenol in combination with halothane (without inhibitor).