Cerebral metabolic rate of oxygen (CMRO₂) expressed in relation to temperature based on the equation ln (CMRO_2 ) = a = b*T where ln is the natural logarithm function, T is the temperature in degrees centigrade, a is the intercept, and b is the slope. Based on data from 41 patients undergoing coronary artery bypass graft surgery at constant pump flows of 2 l/min/m² using alpha-stat blood gas measurement and keeping the PaCO₂ at 35 to 40 mm Hg and blood pressure 50 to 80 mm Hg. Reprinted with permission from Croughwell N, Smith LR, Quill T, Newman M, Greeley W, Kern F, Lu J, Reves JG: The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1992; 103:549–54. Copyright © 1992 Elsevier.