Figure 4. The inhibitory effect of lidocaine on antiaggregation derived from endothelial cells. Antiaggregatory response of endothelial cells without bradykinin stimulation was not influenced by 30-min preincubation with lidocaine (basal; n = 6). In contrast, antiaggregation derived from bradykinin (1 micro Meter)-stimulated endothelial cells was inhibited by 30-min preincubation with lidocaine in a concentration-dependent manner (Bk; n = 6). *Significantly different from absence of lidocaine. Concentrations of lidocaine are expressed as the negative logarithm of molar units and as milligrams per milliliter.