Figure 6. (A) Percentage response of antiaggregation against the concentration of lidocaine (n = 3). Direct application of lidocaine to platelet-rich plasma evoked, in a concentration-dependent manner, antiaggregation of platelets stimulated with collagen (4 micro gram/ml). (B) Effects of 370 micro Meter lidocaine (100 micro gram/ml lidocaine HCl) on platelet antiaggregation evoked by nitric oxide (NO) (B) (filled circles; n = 3) or prostacyclin (PGI²) (C) (filled circles; n = 3). Changes in 50% effective concentrations of NO or PGI²for antiaggregation were not significant with treatment with lidocaine compared with control (open circles = absence of lidocaine; n = 7).