Figure 3. Peak values of potassium current in the presence of ketamine and halothane. Currents were elicited by steps to +50 mV (Vh= -60 or -50 mV). The number of oocytes tested (n) for each data point are indicated in parentheses. This data set contains data previously reported [5]combined with the data from an additional 3 or 4 experiments for each concentration of halothane tested. Data are expressed as a percentage of control currents normalized to 100%. Values are mean+/-SEM. Where there is no error bar, the amplitude of the error was narrower than the symbol. Significantly less inhibition of potassium current was evident for the deletion mutant when compared to the parent channel at 1.35 and 2.7 mM halothane and at all concentrations of ketamine.