Figure 4. The selective kappa-opioid antagonist nor-BNI at concentrations of 10 sup -5 and 10 sup -6 M antagonized the inhibitory effect of the selective kappa-opioid agonist U-50488 H (10 sup -5 M) in a concentration-dependent manner (P < 0.05), suggesting that a kappa-opioid receptor is involved. The effect of 10 sup -7 M nor-BNI was not statistically significant.

Figure 4. The selective kappa-opioid antagonist nor-BNI at concentrations of 10 sup -5 and 10 sup -6 M antagonized the inhibitory effect of the selective kappa-opioid agonist U-50488 H (10 sup -5 M) in a concentration-dependent manner (P < 0.05), suggesting that a kappa-opioid receptor is involved. The effect of 10 sup -7 M nor-BNI was not statistically significant.

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