Figure 10. Simulations of effect-site concentrations (C^e) that result from equipotent bolus and infusion doses of remifentanil and alfentanil using the complete pharmacokinetic-dynamic model. The upper panel represents the effect-site concentrations that result from equipotent bolus doses. The lower panel represents the effect-site concentrations that result from a 2-h computer-controlled infusion targeted to an EC⁵⁰level for each drug. The concentrations on the vertical axis are expressed as a proportion of the maximal effect-site concentration.