Figure 1. Dose-dependent decrease in cerebellar cGMP content in mice treated with dexmedetomidine or clonidine. Values are mean plus/minus SEM and are expressed in percent of the cGMP content in the cerebellum of mice injected with saline. 100% = 2.20 plus/minus 0.30 and 2.42 plus/minus 0.34 pmol cGMP/mg protein for dexmedetomidine (n = 9) and for clonidine (n = 12), respectively. *P < 0.05 compared with 100% (no agonist).