Figure 2. Percent segment shortening (%SS) in the ischemic and reperfused left anterior descending coronary artery (LAD) region. Percent segment shortening (%SS) was significantly (P < 0.05) decreased from baseline during each 5-min LAD occlusion in all groups and also was decreased during each 5-min reperfusion and throughout 180 min of the final reperfusion in drug vehicle- and DPCPX-pretreated dogs. In contrast, %SS recovered to baseline values during the first and second 5-min reperfusions and at 60, 120, and 180 min after the final reperfusion in dogs receiving isoflurane alone. Dogs receiving isoflurane after pretreatment with DPCPX demonstrated maintenance of %SS at baseline values only during the first 5-min reperfusion period. Recovery of %SS after final reperfusion was attenuated in dogs receiving DPCPX and isoflurane compared with those receiving isoflurane alone. (dagger)Significantly (P < 0.05) different from drug vehicle-pretreated dogs. (section)Significantly (P < 0.05) different from DPCPX-pretreated dogs. (double dagger)Significantly (P < 0.05) different from DPCPX-pretreated dogs receiving isoflurane.