Figure 1. Composite left pulmonary vascular pressure-flow (LPQ) plots in six dogs at baseline and after preconstriction with U46619 (*P <0.01) in the conscious state and during sevoflurane anesthesia. Compared with the conscious state, sevoflurane had no net effect on the baseline LPQ relationship. The dose of U46619 was titrated to achieve the same degree of preconstriction in the conscious and sevoflurane-anesthetized states.