Figure 3. Lemakalim dose-response relationship measured in six dogs after preconstriction with U46619 in the conscious state and during sevoflurane anesthesia. The vasodilator response to lemakalim is expressed as the percent decrease in preconstriction with U46619 (defined in methods). Lemakalim-induced pulmonary vasodilation (*P <0.05) was preserved during sevoflurane anesthesia compared with the conscious state.