Figure 8. Lemakalim dose-response relationship measured in five dogs after preconstriction with U46619 with or without pretreatment with indomethacin in the conscious state (top) and during desflurane anesthesia (bottom). Vasodilator response to lemakalim is expressed as the percent decrease in preconstriction with U46619 (defined in Methods). Indomethacin did not alter the magnitude of the pulmonary vasodilator response to lemakalim in the conscious or desflurane-anesthetized states.