![Figure 1. Time-concentration profiles after administration of 20 mg/kg rectal acetaminophen. Parameters [1]used were CL/F, 5.46 ml [center dot] kg sup -1 [center dot] min sup -1; Ka, 0.00468 min sup -1; Vd/F and zero order dissolution times (DT) as shown. The simulations using Vd/F of 1,400 or 2,000 ml/kg assumed rapid dissolution.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/88/4/10.1097_00000542-199804000-00049/2/49ff1.png?Expires=1716614934&Signature=OsHIPgckN9DGM50dbMwqsiTiWCD1hk0ECADOrw9l6h902iI0SeUqCn0KdtEljFUhaOLpHg1ziP5h~1Kw2mdgGKJ8V-Y4-YZ5rrSfu0lb7BfJa5AneGl-jdlV0WzCksBVAAxXDgm5fnsCu6vSFzx5NfKKx8JyEMQVhzihdm37I31WdvD8gGvDu5KJZ~sS5P5DcZY1Q5YOd~54DGAT2Rl9U-HB2cjfc7cxBOSjMmaG0IL6BD1080bPN3kvxpjp9-nxnnbDNth1dzKx1rblepf71cmDZObotAi~ohH08XNAR8LJDCVdEOnb4qJaPf4YHcDUrgziL4pnAwraOahvKi55Xg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 1. Time-concentration profiles after administration of 20 mg/kg rectal acetaminophen. Parameters [1]used were CL/F, 5.46 ml [center dot] kg sup -1 [center dot] min sup -1; Ka, 0.00468 min sup -1; Vd/F and zero order dissolution times (DT) as shown. The simulations using Vd/F of 1,400 or 2,000 ml/kg assumed rapid dissolution.
