Figure 1. (Upper) Time course of inhibition of T1 and T4 after stimulation of abductor digiti minimi in patient 17, who received four successive doses of vecuronium (2, 4, 2, and 2 mg). For clarity, some experimental points are not shown. The time courses of inhibition after all four doses were fitted by the theoretical equations. The equations relating inhibition (f) of T1 and T4 to the concentrations in the effect compartments (Ce) are, respectively:Equation 7. The equations describing time course of Ce after the first dose are shown in the legend to the middle figure. (Middle) Time (t) course of the calculated concentrations of vecuronium in the effect compartments in patient 17. The concentrations are expressed relative to the EC⁵⁰values. From inhibition of T1 and T4, the equations for the first dose are, respectively:Equation 8. Ce accumulates after subsequent doses as described in the text. (Lower) Time course of the calculated concentrations of vecuronium in the central compartment of patient 17. The concentrations (C) are expressed relative to the EC⁵⁰values relevant to inhibition of T1. Equation 9. C accumulates after the first dose as described in the text.