Figure 1. The maximum change in core temperature and the duration of fever exceeding 38 [degree sign]C increased to a total dose of 100,000 IU/kg but subsequently failed to increase further. At that dose, fever magnitude was 1.8 +/- 0.5 [degree sign] Celsius, and the duration was 3.1 +/- 2.0 h. Data are presented as the mean +/- SD.